ORVAL: Oligogenic Resource for Variant AnaLysis

A novel resource for the prediction and exploration of disease-causing oligogenic variant combinations.

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Submit and filter your variants

Submit a variant list of a single individual (VCF or tab-delimited list) and filter your variants based on their Minor Allele Frequency (MAF), their position in the gene and/or based on a specific gene panel of your choice.


Predict disease-causing combinations

Predict pathogenic combinations of variants in any gene pair with VarCoPP and further identify their digenic effect (True Digenic, Monogenic with a Modifier variant or Dual Diagnosis case) with the Digenic Effect Predictor.


Explore oligogenic signatures

Detect oligogenic disease signatures by exploring the gene networks based on the predictions and examine them in the context of their pathways, protein-protein interactions and cellular locations.