ORVAL: Oligogenic Resource for Variant AnaLysis

A platform for the prediction and exploration of candidate disease-causing oligogenic variant combinations

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Submit and filter your variants

Submit a variant list of a single individual (VCF or tab-delimited list) and filter your variants based on their Minor Allele Frequency (MAF), their position in the gene and/or based on a specific gene panel of your choice.


Predict candidate pathogenic combinations

Predict candidate pathogenic combinations of variants in any gene pair with VarCoPP and further predict their digenic effect (True Digenic, Monogenic with a Modifier variant or Dual Diagnosis) with the Digenic Effect Predictor.


Explore oligogenic signatures

Investigate potential oligogenic disease signatures by exploring the predicted gene networks and examine them in the context of their pathways, protein-protein interactions and cellular locations.