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ORVAL: Oligogenic Resource for Variant AnaLysis

A platform for the prediction and exploration of candidate disease-causing oligogenic variant combinations

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Submit and filter your variants

Submit a variant list of a single individual (VCF or tab-delimited list) and filter your variants based on their Minor Allele Frequency (MAF), their position in the gene and/or based on a specific gene panel of your choice.

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Predict candidate disease-causing combinations

Predict candidate pathogenic combinations of variants in any gene pair with VarCoPP and further predict their digenic effect (True Digenic, Monogenic with a Modifier variant or Dual Diagnosis) with the Digenic Effect Predictor.

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Explore oligogenic signatures

Investigate potential oligogenic disease signatures by exploring the predicted gene networks and examine them in the context of their pathways, protein-protein interactions and cellular locations.