orval_logo

ORVAL: Oligogenic Resource for Variant AnaLysis

A novel resource for the prediction and exploration of disease-causing oligogenic variant combinations.

Run it! Learn more »

input_logo

Submit and filter your variants

Submit a variant list of a single individual (VCF or tab-delimited list) and filter your variants based on their Minor Allele Frequency (MAF), their position in the gene and/or based on a specific gene panel of your choice.

predict_logo

Predict disease-causing combinations

Predict pathogenic combinations of variants in any gene pair with VarCoPP and further identify their digenic effect (True Digenic, Monogenic with a Modifier variant or Dual Diagnosis case) with the Digenic Effect Predictor.

network_logo

Explore oligogenic signatures

Detect oligogenic disease signatures by exploring the gene networks based on the predictions and examine them in the context of their pathways, protein-protein interactions and cellular locations.